Product ID:NOLVADEX 10 MG TABLETS
MSDS Date:12/29/1989
FSC:6505
NIIN:01-092-5321
MSDS Number: BGLND

Emergency Phone: 800-327-8633 MEDICAL

Info Phone: 302-886-3000

Cage: 0A273

Telephone: 302-886-3000

Cage: 0A273

TAMOXIFEN CITRATE

CAS: 54965-24-1

RTECS: KH2387000

Fraction By Weight: 10%MG/TB

LD50 LC50 Mixture:2.5 GM/KG
Routes of Entry: Inhalation:YES Skin:NO Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:HIGH DOSE LEVELS MAY CAUSE
INTERFERENCE WITH THE MENSTRUAL CYCLE. SKIN RASH AND CATARACTS MAY
DEVELOP. CAN BE HARMFUL TO DEVELOPING FETUSES. REDUCED FERTILITY
OBSERVED IN MALE ANIMALS. WITHIN 31-37 WE EKS OF 2-YEAR STUDY.
LIVER TUMORS DEVELOPED IN RATS AT DOSES OF 35 MG TAMOXIFEN PER KG
BODYWEIGHT PER DAY.
Effects of Overexposure:INHALATION: SYSTEMIC EFFECTS MAY OCCUR. EYES:
DUST MAY BE SLIGHT IRRITANT. SKIN: LOW POTENTIAL FOR SENSITIZATION.
INGESTION: REPEATED INGESTION OF AMOUNTS >10 MG PER DAY OF ACTIVE
MATERIAL CAN HAVE AD VERSE CLINICAL EFFECTS ON WOMEN OF
CHILDBEARING AGE.
Medical Cond Aggravated by Exposure:NONE GIVEN

First Aid:INHALATION: GET FRESH AIR. IF COUGHING OR OTHER RESPIRATORY
SYMPTOMS DEVELOP, GET MEDICAL ATTENTION. EYES: FLUSH WITH WATER FOR
AT LEAST 15 MINUTES. IF REDNESS, ITCHING, OR IRRITATION DEVELOPS,
GET ME DICAL ATTENTION. SKIN: WASH WITH SOAP AND WATER. IF REDNESS,
ITCHING, OR IRRITATION DEVELOPS, GET MEDICAL ATTENTION. INGESTION:
IRRIGATE MOUTH WITH WATER. REFER PERSON TO MEDICAL PERSONNEL.

Flash Point:NONE
Extinguishing Media:WATER FOG, FOAM, CARBON DIOXIDE, DRY CHEMICAL,
HALON 1211
Fire Fighting Procedures:USE NIOSH APPROVED SELF CONTAINED BREATHING
APPARATUS AND FULL PROTECTIVE EQUIPMENT. USE WATER SPRAY TO COOL
NEARBY CONTAINERS EXPOSED TO FIRE.
Unusual Fire/Explosion Hazard:CAN FORM EXPLOSIVE DUST CLOUDS IN AIR.
SENSITIVE TO IGNITION BY ELECTROSTATIC DISCHARGE, AS DUST CLOUD AND
IN POWDER LAYER. RELEASES FLAMMABLE VAPORS ON HEATING

Spill Release Procedures:USE EYE AND RESPIRATORY PROTECTION. MOISTEN
SPILLAGE AND RECOVER. NEVER SWEEP IN DRY STATE. WASH RESIDUE FROM
SPILL AREA WITH HOT WATER CONTAINING DETERGENT AND FLUSH TO A SEWER
SERVICED BY A WASTEWAT ER TREATMENT FACILITY.

Handling and Storage Precautions:PROTECT FROM LIGHT AND HEAT. MAINTAIN
GOOD HOUSEKEEPING TO AVOID DUST BUILDUP. FOLLOW PROCEDURES IN NFPA
CODES & STDS FOR HANDLING COMBUSTIBLE DUSTS.
Other Precautions:EMPTY CONTAINERS RETAIN PRODUCT RESIDUE. OBSERVE ALL
HAZARD PRECAUTIONS. DO NOT REUSE EMPTY CONTAINERS. REMOVE ALL
PRODUCT RESIDUE AND PUNCTURE/DESTROY EMPTY CONTAINERS BEFORE
DISPOSAL.

Respiratory Protection:IF NEEDED, USE MSHA-NIOSH APPROVED RESPIRATOR
FOR TOXIC PARTICULATES W/TLV < 0.05 MG/CUM
Ventilation:USE LOCAL EXHAUST TO KEEP EXPOSURE TO A MINIMUM.
Protective Gloves:IMPERVIOUS
Eye Protection:CHEMICAL TIGHT GOGGLES
Other Protective Equipment:IMPERVIOUS APRON, EYE WASH STATION
Work Hygienic Practices:WASH CONTAMINATED CLOTHING AND SHOES BEFORE
REUSE.
Supplemental Safety and Health
AT ICI WOMEN OF CHILDBEARING POTENTIAL ARE RESTRICTED FROM WORKING WITH
THIS MATERIAL WHEN EXPOSURES EXCEED 10 MICROGRAMS/CUM 8-HR TWA.

HCC:K2
Solubility in Water:NEGLIGIBLE
Appearance and Odor:WHITE TABLETS

Stability Indicator/Materials to Avoid:YES
NONE KNOWN
Stability Condition to Avoid:HIGH TEMPERATURES
Hazardous Decomposition Products:CARBON MONOXIDE, CARBON DIOXIDE,
NITROGEN OXIDES, OTHER TOXIC VAPORS.

Waste Disposal Methods:NOT LISTED AS A HAZARDOUS WASTE UNDER RCRA, 40
CFR 261. HOWEVER, ICI RECOMMENDS DISPOSAL IN A FACILITY PERMITTED
FOR HAZARDOUS WASTE.

Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.